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目的观察碟脉灵对急性缺血性脑血管病的疗效和副作用。方法对2000年12月—2001年5月在华东、仁济、长海医院神经内科住院的122例发病2周内的急性脑梗塞病人,随机分为两组,碟脉灵治疗组92例,丹参对照组30例,分别在治疗前、治疗后1周、治疗后2周评估其神经功能缺损程度和日常生活自我照顾能力。其中碟脉灵组还有30例病人作了治疗前后血浆纤维蛋白原量的对照。结果1.治疗组总有效率78.26%,对照组总有效率66.67%,差异具有显著性(P<0.05)。2.两组神经功能缺损程度评分在治疗后1周,即有非常显著差异(P<0.001),而日常生活自我照顾能力评分在治疗后1周无显著差异,但治疗后2周差异具有非常显著性(P<0.001)。3.碟脉灵组治疗后纤维蛋白原量明显下降,与治疗前比较有显著差异(P<0.001)。结论碟脉灵注射液能有效改善血液流变学指标,减少缺血性脑血管病人的神经功能缺损,无明显副作用,是一种有效的治疗缺血性脑血管病的药物。
Objective To observe the efficacy and side effects of Diemailing on acute ischemic cerebrovascular disease. Methods A total of 122 patients with acute cerebral infarction who were hospitalized in the Department of Neurology of East China, Renji Hospital and Changhai Hospital from December 2000 to May 2001 were randomly divided into two groups: 92 patients in the Diemailing group, Control group of 30 cases, respectively, before treatment, 1 week after treatment, 2 weeks after treatment to assess the extent of their neurological deficit and self-care ability of daily living. Among them, there are 30 patients in Diemailing group who made the control of plasma fibrinogen before and after treatment. The total effective rate was 78.26% in the treatment group and 66.67% in the control group, the difference was significant (P <0.05). There was a significant difference (P <0.001) between the two groups in the score of neurological deficit at 1 week after treatment, but there was no significant difference in daily life self-care ability score at 1 week after treatment, but the difference was not significant at 2 weeks after treatment Significance (P <0.001). The content of fibrinogen in the group of Diemailing group decreased significantly compared with before treatment (P <0.001). Conclusion Diemailing injection can effectively improve the indexes of hemorheology, reduce the neurological deficits in patients with ischemic cerebrovascular disease, and has no obvious side effects. It is an effective drug for the treatment of ischemic cerebrovascular disease.