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以胃大部切除术(Billroth Ⅰ式)后已恢复健康的人为对象,研究核黄素的不同剂型、不同给药方法的生物利用度及动力学参数,将结果与正常人对比(对照组),探讨提高生物利用度的方法。数据处理按PKPⅡ(2)程序在微型计算机上进行。结果表明,胃大部切除者的核黄素口服吸收率低于正常人,而吸收速度大于正常人,动力学参数Ka、Tmax在胃切除组与对照组间可有非常显著或显著的差异,而β无显著差异。作者认为提高胃大部切除者的核黄素生物利用度,可通过制成释放速度较快的制剂或采用小剂量多次给药的方案来实现。
In order to study the bioavailability and kinetic parameters of different dosage forms of riboflavin and different administration methods, the results were compared with those of normal subjects (control group) , To explore ways to improve bioavailability. Data processing by PKP Ⅱ (2) program on the microcomputer. The results showed that the majority of gastric resection of riboflavin oral absorption rate was lower than normal, and the absorption rate is greater than normal, kinetic parameters Ka, Tmax in the gastrectomy group and the control group can have very significant or significant differences, No significant difference between β. The authors believe that improving the bioavailability of riboflavin in patients with gastric gastrectomy can be achieved by making preparations with faster release rate or using multiple doses in small doses.