论文部分内容阅读
目的探讨胰腺外实性假乳头状肿瘤(ESPT)的临床病理特征及预后。方法报道1例罕见的腹膜后ESPT,结合文献对其临床表现、组织学形态、免疫组化特点及治疗和预后进行分析。结果患儿女性,5岁。查体发现盆腔包块天。镜下肿瘤见纤维性包膜,由形态相对一致的中等大小细胞构成,瘤细胞排列成实性巢片状、假乳头状,伴微囊性变,并可见灶性出血、坏死及钙化。免疫组化:β-catenin、CD99、Syn、vimentin、PR及AACT均不同程度(+),CK、CAM5.2、EMA、CD117、CD34、S-100、CR、CD10和WT-1均(-)。随访半年未见复发和转移。结论 ESPT多发生于卵巢、肾上腺及腹膜后,组织学具有特征性的实性、假乳头状结构。免疫组化检测对其组织起源具有提示意义。手术切除是首选治疗方法,总体预后良好。
Objective To investigate the clinicopathological characteristics and prognosis of extracapsular pancreatic pseudopapillary tumor (ESPT). Methods One case of rare retroperitoneal esophageal varices was reported. The clinical manifestations, histological features, immunohistochemical characteristics, treatment and prognosis of the patients were retrospectively analyzed. Results Children with children, 5 years old. Examination found pelvic mass days. Microscopic tumor see fibrous capsule, composed of medium-sized cells of relatively consistent morphology, tumor cells arranged in a solid nest-like, pseudopapillary, with microcapsule change, and visible focal hemorrhage, necrosis and calcification. Immunohistochemistry showed that the expressions of β-catenin, CD99, Syn, vimentin, PR and AACT were different in all degrees (+), CK, CAM5.2, EMA, CD117, CD34, S-100, CR, CD10 and WT- ). Follow-up no recurrence and metastasis in six months. Conclusion ESPT mostly occurs in the ovary, adrenal gland and retroperitoneum. Histology has the characteristic of solid, pseudopapillary structure. Immunohistochemical detection of its origin of tissue has prompted significance. Surgery is the preferred treatment, the overall prognosis is good.