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目的 探讨Ⅱ期非霍奇金淋巴瘤 (non Hodgkin′slymphoma,NHL)有效的治疗方法。方法对 2 6 8例Ⅱ期NHL患者分别采用单纯放疗、综合治疗 (包括放疗 +化疗、化疗 +放疗 +化疗和化疗 +放疗 )及单纯化疗治疗。结果 Ⅱ期高度恶性NHL经化疗 +放疗 +化疗治疗后 ,1,2 ,3,4,5 ,6年生存率分别为 95 .1%、87.8%、87.8%、85 .4%、82 .9%和 5 3.6 % ,6年复发率为 2 6 .8% ,与单纯放疗、放疗 +化疗和化疗 +放疗组相比 ,生存率有明显提高 (P <0 .0 1) ,6年复发率降低 (P >0 .0 5 )。Ⅱ期中度恶性NHL患者经化疗 +放疗 +化疗治疗后 ,1,2 ,3,4,5 ,6年生存率分别为 89.3%、75 .0 %、6 7.8%、6 0 .6 %、5 7.1%和 46 .4% ,6年复发率为 35 .7% ,与单纯放疗、放疗 +化疗和化疗 +放疗组相比 ,生存率有所提高 (P >0 .0 5 ) ,6年复发率降低 (P >0 .0 5 )。Ⅱ期低度恶性NHL患者经单纯放疗及综合治疗后 ,1,2 ,3,4,5 ,6年生存率及 6年复发率相近。结论 对Ⅱ期中、高度恶性NHL患者应采用化疗 +放疗 +化疗治疗 ,尤其对于高度恶性者 ;Ⅱ期低度恶性NHL患者应采用单纯放疗。
Objective To investigate the effective treatment of stage Ⅱ non-Hodgkin’s lymphoma (NHL). Methods Two hundred and sixty-eight patients with stage II NHL were treated with radiotherapy, comprehensive treatment (including radiotherapy + chemotherapy, chemotherapy + radiotherapy + chemotherapy and chemotherapy + radiotherapy) and chemotherapy alone. Results The survival rates of 1, 2, 3, 4, 5, and 6 years after stage Ⅱ malignant NHL were 95.1%, 87.8%, 87.8%, 85.4% and 82.9% respectively after chemotherapy, radiotherapy and chemotherapy % And 53.6%, respectively. The 6-year relapse rate was 26.8%. Compared with radiotherapy, radiotherapy + chemotherapy and chemotherapy + radiotherapy, the survival rate was significantly increased (P <0.01) Decreased (P> 0.05). The 1, 2, 3, 4, 5, 6-year survival rates of patients with stage Ⅱ moderate malignant NHL after chemotherapy, radiotherapy and chemotherapy were 89.3%, 75.0%, 67.8%, 60.6%, 5 7.1% and 46.4%, respectively. The 6-year recurrence rate was 35.7%. Compared with radiotherapy, radiotherapy + chemotherapy and chemotherapy plus radiotherapy, the survival rate increased (P> 0.05) The rate of decrease (P> 0.05). Stage Ⅱ low grade NHL patients after radiotherapy and comprehensive treatment, 1,2, 3,4,5, 6-year survival rate and 6-year recurrence rate were similar. Conclusions Chemotherapy + radiotherapy + chemotherapy should be used in patients with moderate or high grade II NHL, especially for those with high grade II. Patients with stage II low grade NHL should be treated with radiotherapy alone.