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目的：拟通过检测慢性肾脏病患者血清Hs-CRP及肌酐、尿素氮，初步探讨慢性肾脏病患者微炎症反应状态与肾功能的相关性。方法：我院住院治疗且诊断明确的1-4期CKD 患者100例、在体检中心行健康体检者20例(正常组)作为研究对象。收集受试对象的外周血标本，检测Hs-CRP及肌酐、尿素氮。结果：两组患者年龄无明显差异，两组间BUN，Cr, Hs-CRP有显著性差异，CKD组BUN，Cr，CRP明显高于正常对照组（P＜0.05）。结论：Hs-CRP作为炎症反应的重要细胞因子,可能参与了慢性肾脏病患者的微炎症反应,微炎症因子在慢性肾脏病发生及病情进展中发挥重要作用。“,”Objective: To study the correlation between serum Hs-CRP, creatinine and urea nitrogen in patients with chronic kidney disease, and to explore the relationship between the micro inflammatory reaction and renal function in patients with chronic kidney disease.Methods: in our hospital, 100 cases of CKD patients with clear diagnosis of 1-4 and 20 cases of healthy physical examination in the physical examination center were used as the research objects. Peripheral blood samples were collected to detect Hs-CRP, creatinine and urea nitrogen.Results:there were no significant differences in age between the two groups, BUN, Cr, Hs-CRP, CKD, BUN, Cr, CRP in the two groups was significantly higher than that in the control group (P < 0.05).Conclusion: Hs-CRP is an important cytokine in the inflammatory response, which may play an important role in the occurrence and progression of chronic kidney disease in patients with chronic kidney disease.