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目的探讨肠内免疫微生态营养(EIN)对神经危重患者预后的影响。方法 89例神经重症患者均经鼻胃管行肠内营养(EN)支持,其中43例(EIN组)加用L-谷氨酰胺0.4g·kg-1·d-1、L-精氨酸0.25g·kg-1·d-1、三联活菌制剂6g/d,每天3次。检测两组治疗7、14d血清炎症指标及相关临床指标变化。结果入院后第7、14天两组患者血清清蛋白、前清蛋白水平均升高(P<0.05)。入院后第7、14天两组患者TNF-α、IL-6水平均下降(P<0.05),且EIN组下降更明显(P<0.05)。EIN组肺部感染发生率、呼吸机使用天数、28d病死率均低于46例仅EN治疗组(P<0.05)。结论 EIN可减少神经重症患者并发症发生,改善临床预后。
Objective To investigate the effect of enteral immune microecological nutrition (EIN) on the prognosis of patients with neurological crisis. Methods Eighty-nine patients with neuroticism were enrolled in the study. Enteral nutrition (EN) was used in nasogastric tube patients. Forty-three patients (EIN group) received L-glutamine 0.4g · kg-1 · d-1 and L-arginine 0.25g · kg-1 · d-1, triple viable preparations 6g / d, 3 times a day. The levels of serum inflammation and related clinical indexes in the two groups were detected at 7 and 14 days after treatment. Results On the 7th and 14th days after admission, serum albumin and prealbumin levels were increased in both groups (P <0.05). On the 7th and 14th day after admission, the levels of TNF-α and IL-6 in both groups decreased (P <0.05), and decreased more significantly in EIN group (P <0.05). The incidence of pulmonary infection, days of ventilator use, and mortality at 28 days in EIN group were all lower than those in EN-only group (P <0.05). Conclusion EIN can reduce the incidence of complications in neurotic patients and improve the clinical prognosis.