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目的：评价比较基因组杂交（ＣＧＨ）技术在白血病研究中应用的价值。方法：应用ＣＧＨ技术检测高二倍体急性淋巴细胞白血病（ＡＬＬ）患者１４例，并与核型分析结果相比较。结果和结论：发现在高二倍体ＡＬＬ中，部分和（或）整条染色体的增加比减少常见，两者相差７倍，其中２１号和Ｘ染色体的增加最为常见。ＣＧＨ与常规Ｒ带的分析结果比较可分为三种：①ＣＧＨ和常规核型分析结果完全一致的有３例；②ＣＧＨ分析和Ｒ带分析从不同角度提供了相对一致信息的有８例；③ＣＧＨ分析和Ｒ带分析结果不一致的有３例，其中２例分别为约三倍体和约四倍体，另１例为正常／＋２２嵌合型
Objective: To evaluate the value of comparative genomic hybridization (CGH) technology in leukemia research. METHODS: Fourteen patients with high diploid acute lymphoblastic leukemia (ALL) were examined by CGH technique and compared with the results of karyotype analysis. RESULTS AND CONCLUSION: It was found that in the high diploid ALL, the increase ratios of the partial chromosomes and (or) whole chromosomes were common, and the difference between the two was 7-fold. Among them, the increase of No.21 and X chromosomes was the most common. The analysis results of CGH and conventional R bands can be divided into three types: 1 There are 3 cases of CGH and conventional karyotype analysis results are identical; 2 CGH analysis and R band analysis provide 8 cases of relatively consistent information from different angles; 3 CGH analysis Three cases were inconsistent with the results of the R-band analysis, of which 2 were about triploid and about tetraploid, and the other 1 was normal/+22 chimeric.