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目的观察小剂量多巴胺与多巴酚丁胺治疗慢性心衰合并肾功能不全的临床疗效,探讨正变力性药物在治疗慢性心衰合并肾功能不全中的作用。方法选取2007年1月至2010年12月在我院内科多次住院治疗的慢性心衰合并肾功能损害的患者76例,随机分为观察组38例,对照组38例。基础治疗均为控制液体入量、利尿、扩张血管,对照组加用洋地黄治疗,观察组采用小剂量多巴胺及多巴酚丁胺治疗3～5d后比较疗效。结果与治疗前比较,两组患者症状均有改善;两组治疗后比较,观察组优于对照组(P<0.01);两组不良事件发生情况比较,观察组不良事件明显少于对照组(P<0.01)。结论小剂量多巴胺与多巴酚丁胺在治疗慢性心衰合并肾功能不全方面优于单纯使用洋地黄制剂。
Objective To observe the clinical efficacy of low-dose dopamine and dobutamine in the treatment of chronic heart failure with renal insufficiency and to explore the role of positive-acting drugs in the treatment of chronic heart failure complicated with renal insufficiency. Methods From January 2007 to December 2010 in our hospital multiple hospitalized patients with chronic heart failure and renal dysfunction, 76 patients were randomly divided into observation group 38 cases and control group 38 cases. The basic treatment were controlled liquid intake, diuretic, dilation of blood vessels, the control group with digitalis treatment, the observation group with small doses of dopamine and dobutamine treatment of 3 ~ 5d after the curative effect. Results Compared with those before treatment, the symptoms of both groups were improved. After treatment, the observation group was better than the control group (P <0.01). The adverse events in the two groups were significantly less than those in the control group P <0.01). Conclusion Low-dose dopamine and dobutamine are superior to digitalis in the treatment of chronic heart failure and renal insufficiency.