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目的探讨无创正压通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)急性加重期合并Ⅱ型呼吸衰竭的治疗作用。方法42例COPD急性加重期合并Ⅱ型呼吸衰竭的患者随机分为两组:NIPPV治疗组21例,常规对照组21例,观察患者的生命体征和血气分析。结果治疗4h后NIPPV治疗组和常规对照组动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、呼吸频率均有明显改善,并且NIPPV治疗组明显优于常规对照组(P<0.05)。NIPPV治疗组病死率、住院天数较常规对照组明显降低(P<0.05)。结论NIPPV可明显改善COPD急性加重期合并Ⅱ型呼吸衰竭的通气,可明显缩短住院天数,降低病死率。
Objective To investigate the therapeutic effect of noninvasive positive pressure ventilation (NIPPV) on type Ⅱ respiratory failure in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Forty-two patients with acute exacerbation of COPD and type Ⅱ respiratory failure were randomly divided into two groups: 21 in NIPPV-treated group and 21 in control group. The vital signs and blood gas analysis were observed. Results After 4 hours of treatment, the PaO2, PaCO2 and respiratory rate of NIPPV group and conventional control group were significantly improved, and the NIPPV group was significantly better than the conventional control group (P <0.05). The mortality and hospital stay in NIPPV group were significantly lower than those in control group (P <0.05). Conclusion NIPPV can significantly improve the COPD acute exacerbation of type Ⅱ respiratory failure ventilation, can significantly shorten the length of stay and reduce mortality.