论文部分内容阅读
目的探讨在经体外受精(in vitro fertilization,IVF)或单精子卵母细胞浆内注射(Intracytoplasmic sperm injection,ICSI)-胚胎移植冻融周期(Embryo freezing and thawing cycles,ET)(IVF/ICSI-ET)治疗的单胎及双胎早期妊娠中血清催乳素(prolactin,PRL)的变化趋势及差异,并评估其对先兆流产的预测价值。方法回顾性分析2015年8月至2016年2月在安徽医科大学第一附属医院生殖中心行IVF/ICSI-ET并获得妊娠的妇女281例,根据B超单双胎及有无阴道流血分为:单胎组163例(正常妊娠114例,先兆流产49例),双胎组118例(正常妊娠70例,先兆流产48例),检测各组妊娠前PRL值及妊娠6~9周时PRL值。结果各组在年龄、不孕类型、不孕年限、周期类型、基础血清催乳素等方面差异均无统计学意义(P>0.05),妊娠后PRL值较基础PRL值明显升高,单胎组和双胎组早期妊娠PRL值差异有统计学意义(P<0.05),但单胎正常组与先兆流产组、双胎正常组与先兆流产组之间催乳素值差异均无统计学意义(P>0.05)。结论PRL值在早孕期明显上升,且在双胎妊娠中PRL值上升更显著,但对于判断先兆流产预后价值仍有待进一步研究。
OBJECTIVE: To investigate the effects of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) -embryo freezing and thawing cycles (ET) (IVF / ICSI-ET ) Prolactin (prolactin, PRL) in the treatment of singleton and twin pregnancies, and to evaluate its predictive value for threatened abortion. Methods A retrospective analysis of 281 women with IVF / ICSI-ET who received pregnancy at the Reproductive Center of the First Affiliated Hospital of Anhui Medical University between August 2015 and February 2016 was conducted according to B-type single twins and vaginal bleeding : 163 cases of single fetus (normal pregnancy in 114 cases, 49 cases of threatened abortion), twins in 118 cases (70 cases of normal pregnancy, threatened abortion in 48 cases), PRL value of each group before pregnancy and pregnancy 6 to 9 weeks PRL value. Results There was no significant difference in age, type of infertility, duration of infertility, cycle type, basal serum prolactin and other aspects (P> 0.05). After pregnancy, the PRL was significantly higher than the basic PRL, (P <0.05). However, there was no significant difference in prolactin values between the normal single group and the threatened abortion group, the normal twin group and the threatened abortion group (P <0.05) > 0.05). Conclusion The PRL value increased significantly in early pregnancy, and the PRL value increased more significantly in twin pregnancy. However, the prognostic value of threatened abortion remains to be further studied.