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目的探讨早发型重度子痫前期期待治疗及与母儿结局的关系。方法回顾性分析2003年1月-2013年1月收治的92例早发型重度子痫前期患者,根据患者入院后期待治疗时间分为3组:A组(35例)治疗时间≤48 h,B组(36例)治疗时间为3~10 d,C组(35例)治疗时间≥10 d。比较不同期待治疗时间与围产结局的关系,包括围生儿结局及母体并发症发生情况。结果 A、B两组低蛋白血症、肾功能损害、胎盘早剥、子痫发生率均显著低于C组(P<0.05)。C组围生儿舒张期血流逆转/消失发生率显著高于A、B两组(P<0.05)。A组围生儿死亡率及新生儿窒息率显著高于B、C两组(P<0.05)。结论早发型重度子痫前期严密监测下期待治疗3~10 d能够显著降低围生儿死亡率,改善预后,而并不增加孕产妇并发症。
Objective To investigate the relationship between expectant treatment of early-onset severe preeclampsia and maternal and infant outcomes. Methods Ninety-two patients with early-onset severe preeclampsia were enrolled in this study from January 2003 to January 2013. The patients were divided into three groups according to the expected treatment time after admission: group A (n = 35), treatment time Group (36 cases) for 3 to 10 days, C group (35 cases) for more than 10 days. Compare the relationship between expectant treatment duration and perinatal outcome, including the outcome of perinatal infants and maternal complications. Results A, B hypoproteinemia, renal damage, placental abruption, eclampsia were significantly lower than the C group (P <0.05). The incidence of diastolic blood flow reversal / disappearance in group C was significantly higher than that in group A and B (P <0.05). Perinatal mortality and neonatal asphyxia in group A were significantly higher than those in groups B and C (P <0.05). Conclusions Early monitoring of preeclampsia with severe preeclampsia can shorten the perinatal mortality rate and improve the prognosis, but does not increase the incidence of maternal complications.