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建立了毛细管电泳-紫外检测法测定硝酸咪康唑乳膏、小儿止咳糖浆及复方苦参水杨酸散中苯甲酸和山梨酸钾的方法。在230nm波长处以焦性没食子酸为内标物,分离电压为20kV,分离温度为25℃,用20mmol/L硼砂缓冲液(pH9.2)作毛细管电泳的运行液,被测组分与内标物得到快速分离。苯甲酸和山梨酸钾的进样质量浓度在1～400mg/L范围内与电泳峰面积呈良好的线性关系,相关系数r均为0.9999,检出限均为0.15mg/L。方法可用于药品中苯甲酸和山梨酸钾含量的测定。
A method for the determination of benzoic acid and potassium sorbate in miconazole nitrate cream, pediatric antitussive syrup and compound kushen salicylic acid was established by capillary electrophoresis and ultraviolet detection. At 230nm wavelength of the focus of gallic acid as the internal standard, the separation voltage of 20kV, the separation temperature was 25 ℃, with 20mmol / L borax buffer (pH9.2) for capillary electrophoresis running solution, the measured components and internal standard Things get quickly separated. The injection mass concentration of benzoic acid and potassium sorbate in the range of 1 ~ 400mg / L showed a good linear relationship with the electrophoretic peak area, the correlation coefficient r was 0.9999, the detection limits were 0.15mg / L. The method can be used for the determination of benzoic acid and potassium sorbate in medicine.