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Cross sections of the 10B(n, α) 7Li reaction (including the total, the "leaking" alpha, forward alpha and backward alpha parts) at En=4.0 and 5.OMcV were measured using an asymmetrical twin gridded ionization chamber and two back-to-back 10B samples.Measurements were performed at the 4.5MV Van de Graaff accelerator of Peking University.Monoenergetic neutrons were produced through the 2H(d, n)3 He reaction with a deuterium gas target.Absolute neutron flux was determined by a 238 U sample set inside the gridded ionization chamber and a BF3 long counter was employed as a neutron flux monitor and for normalization.The present results are compared with previous measurements and evaluations.