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目的:研究135例2型糖尿病患者神经-内分泌-免疫网络的紊乱状态。方法:收集2型糖尿病患者共135例,正常对照组33例。对所有研究对象进行以下指标的测定:血清辅助/抑制T细胞比值(CD3+CD4+/CD3 +CD8+)及自然杀伤(NK)细胞数;血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNFα)和皮质醇(CORT),血浆促肾上腺皮质激素(ACTH);血浆多巴胺(DA)、去甲肾上腺素(NE)。结果:2型糖尿病患者CD4、CD8、NK细胞数及ACTH、CORT均低于正常对照组(P<0.01);IL-1β、IL 6和TNF-α水平均高于正常对照组(P<0.01);NE、DA均高于正常对照组(P<0.05);CD4/CD8比值与正常对照组比较无统计学意义(P>0.05)。结论:机体神经内分泌免疫网络功能的紊乱是糖尿病发生和发展的重要因素之一。
Objective: To investigate the disorder of neuroendocrine-immune network in 135 type 2 diabetic patients. Methods: A total of 135 patients with type 2 diabetes mellitus and 33 normal controls were collected. All subjects were tested for the following parameters: Serum Assisted / Inhibit T Cell Ratio (CD3 + CD4 + / CD3 + CD8 +) and Natural Killer (NK) Cell Count; Serum Interleukin- 1 Beta (IL-6), tumor necrosis factor (TNFα) and cortisol (CORT), plasma adrenocorticotropic hormone (ACTH), plasma dopamine (DA) and norepinephrine (NE). Results: The numbers of CD4, CD8, NK cells and ACTH and CORT in type 2 diabetic patients were significantly lower than those in normal controls (P <0.01). The levels of IL-1β, IL-6 and TNF- ), NE and DA were higher than those in normal control group (P <0.05). There was no significant difference in CD4 / CD8 ratio between normal control group and normal control group (P> 0.05). Conclusion: The disorder of function of neuroendocrine and immune network is one of the important factors in the occurrence and development of diabetes mellitus.