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采用放射免疫、生物学方法测定２３例老年脑梗塞患者，２８例老年高血压患者及２０例正常对照组血浆血小板活化因子（ＰＡＦ）、血栓素Ｂ２（ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋ－ＰＧＦ１α）水平。对９例老年脑梗塞患者和１４例老年高血压患者作应激状态下血浆ＰＡＦ、ＴＸＢ２和６－ｋ－ＰＧＦ１α测定。结果表明，老年脑梗塞患者血浆ＰＡＦ、ＴＸＢ２较健康对照组显著增高（Ｐ＜０．０１），老年高血压患者血浆ＴＸＢ２与健康对照组比较显著增高（Ｐ＜０．０１），但ＰＡＦ、６－ｋ－ＰＧＦ１α无显著差异（Ｐ＞０．０５）。老年脑梗塞患者应激后ＰＡＦ、ＴＸＢ２增加明显（Ｐ＜０．０１），且持续时间长。这些结果表明血浆ＰＡＦ、ＴＸＢ２和６－ｋ－ＰＧＦ１α检测对老年心脑血管疾病的诊断、治疗和预后有一定的临床价值。
Twenty-three elderly patients with cerebral infarction, 28 elderly hypertensive patients and 20 normal controls were measured for plasma platelet activating factor (PAF), thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α 6-k-PGF1α) levels. The plasma PAF, TXB2 and 6-k-PGF1α levels were measured in 9 elderly patients with cerebral infarction and 14 elderly patients with hypertension. The results showed that the levels of plasma PAF and TXB2 in elderly patients with cerebral infarction were significantly higher than those in healthy controls (P <0.01), and the levels of plasma TXB2 in elderly hypertensive patients were significantly higher than those in healthy controls (P <0.01) -k-PGF1α no significant difference (P> 0.05). PAF and TXB2 increased significantly in elderly patients with cerebral infarction (P <0.01), and persisted for a long time. These results indicate that plasma PAF, TXB2 and 6-k-PGF1α detection of cardiovascular disease in elderly with diagnosis, treatment and prognosis of a certain clinical value.