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目的:观察辛伐他汀治疗儿童肾病综合征高脂血症的临床疗效。方法:将肾病综合征患儿55例随机分为治疗组和对照组,其中治疗组30例、对照组25例。对照组给予泼尼松治疗,治疗组在泼尼松治疗的基础上加用辛伐他汀,治疗4周后分别检测两组患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)和载脂蛋白B(apoB)水平。结果:治疗组在治疗4周后TC、TG、LDL、apoB水平明显低于对照组(P<0.01)。结论:辛伐他汀治疗儿童肾病综合征高脂血症有较好的临床疗效。
Objective: To observe the clinical effect of simvastatin on children with nephrotic syndrome and hyperlipidemia. Methods: 55 cases of children with nephrotic syndrome were randomly divided into treatment group and control group, of which 30 cases in the treatment group and 25 cases in the control group. The control group was treated with prednisone. The treatment group was given simvastatin on the basis of prednisone treatment. After 4 weeks of treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipids Protein cholesterol (LDL) and apolipoprotein B (apoB) levels. Results: The levels of TC, TG, LDL and apoB in the treatment group after 4 weeks of treatment were significantly lower than those in the control group (P <0.01). Conclusion: Simvastatin in children with nephrotic syndrome has a good clinical efficacy of hyperlipidemia.