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预防药物性耳中毒有很重要的意义,因为耳中毒后往往治疗无效。主要是对耳中毒的发病机制缺乏深入研究。用放射免疫学、生物生理学和组织化学等方法所做的动物实验指出,抗生素性耳中毒初起的发病机制,前列腺素起一定作用。前列腺素具有控制其他生物活性物质(乙酰胆碱、肾上腺素、5-羟色胺)的重要功能,对于机体内环境的稳定起很大作用。由于对耳有毒性的抗生素使血-迷路屏障和耳蜗的薄膜结构与血管发生不良反应,而前列腺素F_2,参与不良反应的发生。
Prevention of drug-induced ototoxicity is very important, because the treatment is often ineffective after ear poisoning. The main is the lack of in-depth study on the pathogenesis of ototoxicity. Animal experiments using radioimmunoassay, bio-physiology and histochemistry suggest that prostaglandins play a role in the pathogenesis of antibiotic-induced ototoxicity. Prostaglandins have the important function of controlling other bioactive substances (acetylcholine, epinephrine, serotonin) and play a great role in the stability of the environment in the body. Because of the toxicity of the ear antibiotics make the blood - labyrinth barrier and cochlear membrane structure and vascular adverse reactions, and prostaglandin F_2, involved in the occurrence of adverse reactions.