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目的探究分别采用异甘草酸镁注射液与复方甘草酸苷注射液治疗对慢性肝炎患者的临床疗效。方法选取2014年6月—2016年9月新乡医学院第三附属医院收治的108例慢性肝炎患者作为研究对象,随机分为观察组与对照组,每组54例。在常规保肝的治疗基础上,观察组采用异甘草酸镁静脉滴注治疗,而对照组采用复方甘草酸苷静脉滴注治疗,两组均治疗1个月,比较治疗前后的肝功能指标谷丙氨酸转移酶(ALT)、天冬氨酸氨基转氨酶(AST)和总胆红素(TBIL)变化水平及临床症状改善情况。结果治疗后,观察组与对照组患者ALT、AST和TBIL水平均显著下降,且观察组较对照组下降明显,差异有统计学意义(P<0.05);观察组治疗总有效率为96.30%,高于对照组的83.33%,差异有统计学意义(P<0.05)。结论异甘草酸镁用于治疗慢性肝炎患者疗效显著,不良反应发生情况少。
Objective To investigate the clinical effects of magnesium glycyrrhizinate injection and compound glycyrrhizin injection on patients with chronic hepatitis. Methods A total of 108 chronic hepatitis patients admitted to the Third Affiliated Hospital of Xinxiang Medical College from June 2014 to September 2016 were selected as study subjects and randomly divided into observation group and control group with 54 cases in each group. On the basis of routine hepatoprotective therapy, the observation group was treated with intravenous injection of isoglycyrrhizin, while the control group was treated with intravenous infusion of compound glycyrrhizin. Both groups were treated for one month. The changes of hepatic function indexes such as glutamic acid (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) levels and clinical symptoms improved. Results After treatment, the levels of ALT, AST and TBIL in the observation group and the control group were significantly decreased, and the observation group decreased significantly compared with the control group (P <0.05); the total effective rate in the observation group was 96.30% Higher than 83.33% of the control group, the difference was statistically significant (P <0.05). Conclusion Magnesium isoglycyrrhizinate is effective in treating patients with chronic hepatitis, with less adverse reactions.