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目的 :研究热休克蛋白 90α(HSP90α)在人胃癌与癌旁及淋巴结转移癌中的表达。方法 :应用兔抗人HSP90α多克隆抗体SP免疫组化方法检测 93例胃癌、癌旁和淋巴结转移癌组织。结果 :HSP90α在胃癌、胃旁及淋巴结转移癌中的阳性率分别为 86.5 %、5 9.5 %、71.4 %。HSP90α在胃癌中的表达率高于癌旁 (P <0 .0 5 ) ,而与淋巴结转移癌差异不显著。结论 :HSP90α在人胃癌中表达值高于癌旁 ,此现象说明HSP90α和癌的产生和发展有密切联系。
Objective: To study the expression of heat shock protein 90α (HSP90α) in human gastric cancer and its adjacent tissues and lymph node metastases. Methods: The anti-human HSP90α polyclonal antibody SP immunohistochemical method was used to detect 93 cases of gastric cancer, paracancer and lymph node metastasis. Results: The positive rates of HSP90α in gastric cancer, gastric cancer and lymph node metastasis were 86.5%, 5 9.5% and 71.4% respectively. The expression of HSP90α in gastric cancer was higher than that in adjacent tissues (P <0.05), but not significantly different from that in lymph node metastases. Conclusion: The expression of HSP90α in human gastric cancer is higher than that in adjacent tissues, indicating that there is a close relationship between HSP90α and carcinogenesis and development.