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骆驼蓬总生物碱,经临床验证能改善消化道肿瘤病人的临床症状。本文用骆驼蓬总生物碱注射液,依据大多数药物的血药浓度和药效、毒性呈平行关系这一原理。采用药物累积法,把药物动力学中血药浓度多点动态测定的原则与动物急性死亡率测定蓄积性的方法结合起来。以小鼠急性死亡率机率单位作为分级定量的药理效应指标,通过剂量效应曲线,转换成相应的体内药物水平。以了解骆驼蓬总碱注射液在动物体内的代谢规律,并推算其主要动力学参数,供临床用药参考。
The total alkaloids of Peganum harmonii have been clinically proven to improve the clinical symptoms of patients with digestive tract tumors. This article uses the total alkaloid injection of Peganum harmonius, according to the principle of parallel relationship between the blood drug concentration, efficacy and toxicity of most drugs. The drug accumulation method was used to combine the principle of multi-point dynamic measurement of blood drug concentration in pharmacokinetics with the method of determining accumulation of acute mortality in animals. The mouse acute mortality probability unit was used as a quantitative pharmacological effect indicator, and converted to a corresponding in vivo drug level through a dose-response curve. In order to understand the metabolism of total alkaloid injection of Peganum harmoni in animals, and to calculate its main kinetic parameters for clinical reference.