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目的:探讨YB-1蛋白在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法:采用免疫组织化学法检测49例NSCLC患者肺癌组织标本中YB-1蛋白的表达情况并与癌旁组织比较。结果:49例NSCLC中YB-1蛋白在细胞核中的阳性率为49%,且与病理类型、临床分期及有无淋巴结转移呈相关性,而与分化程度、性别及年龄无相关性;YB-1蛋白在正常肺组织中无表达。结论:YB-1蛋白的检测有利于对NSCLC患者的诊断、局部淋巴结转移和预后情况作出客观判断。
Objective: To investigate the expression of YB-1 protein in non-small cell lung cancer (NSCLC) and its clinical significance. Methods: The expression of YB-1 protein in lung cancer specimens from 49 patients with NSCLC was detected by immunohistochemistry and compared with that of paracancerous tissues. Results: The positive rate of YB-1 protein in 49 NSCLCs was 49% in the nucleus and was correlated with the pathological type, clinical stage and lymph node metastasis, but not with the degree of differentiation, sex and age. YB- 1 protein is not expressed in normal lung tissue. Conclusion: The detection of YB-1 protein is helpful to make an objective judgment on the diagnosis, local lymph node metastasis and prognosis of NSCLC patients.