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选择 79例糖尿病合并肾病的住院病人 ,随机分组 ,在控制血糖的同时分别予前列腺素E1 10 0ug静脉滴注 ,每日 1次或予福辛普利 1 0mg/日 ,晨起空腹顿服 ,疗程均为 2周。比较治疗前后病人的 2 4小时尿微量白蛋白 (u-MA)及尿总蛋白 (TP)的变化。结果 :上述两种药物均能有效控制糖尿病肾病患者尿蛋白的进行性升高 ,但两组间比较无统计学意义 (P >0 0 5 )。结论 :两种药物对于降低糖尿病肾病患者尿蛋白均有较好疗效。
Inpatients with diabetes mellitus and nephropathy were randomly divided into control group and control group. The control group received intravenous infusion of prostaglandin E1 10 μg once daily or fosinopril 10 mg daily for fasting, The course of treatment is 2 weeks. The 24-hour urine microalbumin (u-MA) and urinary total protein (TP) in patients before and after treatment were compared. Results: Both of the above two drugs could effectively control the progressive increase of urinary protein in patients with diabetic nephropathy, but there was no significant difference between the two groups (P> 0.05). Conclusion: The two drugs have a good effect on reducing urinary protein in patients with diabetic nephropathy.