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用含不同浓度对苯二甲酸的饲料给大鼠经口染毒，共饲养八周，观察一般情况，并分别在染毒后第１、３、８周末测定尿、血及骨中各生化指标，结果表明，各组染毒大鼠尿中ｃａ２＋、ＮＨ４＋、ｐＨ、血清白蛋白等指标在各组有显著性差异，且其中一些指标呈显著的相关关系，而尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶、血钙、骨钙、及血清碱性磷酸酶、谷丙转氨酶与对照组相比未见显著性差异。作者指出，尿中ＮＨ４＋的变化可作为制订ＴＰＡ接触限值的保护水平。
Rats with different concentrations of terephthalic acid were orally exposed to a total of eight weeks of feeding. The general conditions were observed. Urine, blood and bone biochemical markers , The results showed that urine exposure in each group ca2 +, NH4 +, pH, serum albumin and other indicators in each group were significantly different, and some of the indicators showed a significant correlation between urine N-acetyl-β-D - glucosaminidase, serum calcium, bone calcium, and serum alkaline phosphatase, alanine aminotransferase compared with the control group no significant difference. The authors note that changes in urinary NH4 + can be used as a protection against TPA exposure limits.