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目的探讨银杏达莫注射液对急性缺血性脑卒中患者血清C反应蛋白(CRP)的影响。方法将72例急性缺血性脑卒中患者随机分为治疗组(36例)与对照组(36例),对照组患者给予常规治疗,治疗组患者给予常规治疗的基础上加用银杏达莫注射液20 ml/d,疗程均为14 d。治疗前后分别测定患者血清CRP水平并进行神经功能缺损程度(NIHSS)和日常生活能力(ADL)评分。结果治疗前,两组患者血清CRP水平及NIHSS、ADL评分与对照组比较,差异无统计学意义(P>0.05)。治疗14 d后,与对照组比较,治疗组临床疗效优于对照组(P<0.05),治疗组患者血清CRP水平明显降低,ADL评分明显升高,差异均有统计学意义(P<0.01)。结论银杏达莫注射液对急性缺血性脑卒中患者的治疗作用可能与其降低患者血清CRP水平、抑制炎症反应有关。
Objective To investigate the effect of Yinxingdamo injection on serum C-reactive protein (CRP) in patients with acute ischemic stroke. Methods Seventy-two patients with acute ischemic stroke were randomly divided into treatment group (36 cases) and control group (36 cases). Patients in control group were given routine treatment. Patients in treatment group were given routine treatment, Liquid 20 ml / d, treatment for 14 d. Serum CRP level was measured before and after treatment, and NIHSS and ADL scores were also measured. Results Before treatment, serum CRP levels and NIHSS, ADL scores of two groups were not significantly different from those of the control group (P> 0.05). After 14 days of treatment, compared with the control group, the clinical efficacy of the treatment group was better than that of the control group (P <0.05). The serum CRP level was significantly lower and the ADL score was significantly higher in the treatment group (P <0.01) . Conclusion The therapeutic effect of Yinxingdamo injection on patients with acute ischemic stroke may be related to reducing serum CRP level and inhibiting inflammatory reaction.