论文部分内容阅读
目的了解驻马店市手足口病病原学流行特征。方法收集2011-2013年间,全市县级以上医疗机构门诊就诊或住院的手足口患者的粪便或肛拭子标本,共610份。采用实时荧光RT-PCR法对送检标本进行肠道病毒71型(EV71)、柯萨奇病毒A组16型(CoxAl6)和其他肠道病毒核酸检测。结果共检测标本610份,阳性标本422例,总阳性率69.18%,阳性标本中EV71、CovA16和其他肠道病毒构成比分别为55.45%、(234/422)、13.27%(56/422)和31.28%(132/422)。不同年份阳性率差异无统计学意义(x2=0.745,P>0.05),但不同年份间阳性标本构成比分布的差异具有统计学意义(x2=57.765,P<0.01),重症病例与普通病例阳性率的差异有统计学意义(x2=14.408,P<0.01)。结论我市手足口病病原分布以EV71为流行优势株,其它肠道病毒所占比重有上升趋势,重症病例感染以EV71为主。
Objective To understand the epidemiological characteristics of HFMD in Zhumadian City. Methods A total of 610 fecal or anal swab samples of hand, foot and mouth patients from outpatient clinics or inpatients at the medical institutions above the county level from 2011 to 2013 were collected. Real-time fluorescence RT-PCR method was used to detect EV71, CoxAl6 and other enterovirus nucleic acids in the samples. Results A total of 610 samples were positive and 422 were positive, with a positive rate of 69.18%. The positive rates of EV71, CovA16 and other enteroviruses were 55.45%, 234/422, 13.27% (56/422) and 31.28% (132/422). There was no significant difference in the positive rates of different years (x2 = 0.745, P> 0.05), but there was a significant difference in the distribution of positivities in different years (x2 = 57.765, P <0.01) Rate difference was statistically significant (x2 = 14.408, P <0.01). Conclusion The prevalence of HFMD in our city is predominantly EV71, and the proportion of other enteroviruses is on the rise. EV71 is the predominant case of severe cases.