日本Kamisu地区化学武器导致二苯胂酸中毒

• 作 者: Ishii K. Tamaoka A 黄卫东
• 机 构: Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tennoudai 1- 1- 1, T
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2005年04期
• 关键词: 苯胂酸 化学武器 二苯氰胂 二苯氯胂 小脑症状 智力发育迟缓 临床综合征 降解产物 饮用水 水井

We noted a new clinical syndrome with prominent cerebellar symptoms in apartment building residents in Kamisu, Japan. The well that provided drinking water contained diphenylarsinic acid, a degradation product of diphenylcyanoarsine or diphenylchloroarsine, which were developed for use as chemical weapons, inducing severe vomiting and sneezing. Characteristics of diphenylarsinic acid poisoning include brain- stem- cerebellar and cerebral symptoms. Mental retardation associated with brain atrophy in magnetic resonance images was evident in some infants. We must be vigilant to prevent or minimize the effects of further diphenylarsinic acid poisoning in Japan or elsewhere.

We noted a new clinical syndrome with prominent cerebellar symptoms in apartment building residents in Kamisu, Japan. The well that provided drinking water contained diphenylarsinic acid, a degradation product of diphenylcyanoarsine or diphenylchloroarsine, which were developed for use as chemical weapons, inducing severe vomiting and Characteristics of diphenylarsinic acid poisoning include brain-stem-cerebellar and cerebral symptoms. Mental retardation associated with brain atrophy in magnetic resonance images was evident in some infants. We must be vigilant to prevent or minimize the effects of further diphenylarsinic acid poisoning in Japan or elsewhere.