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建立鉴别体液中阿普唑仑及其主要代谢物的高效液相色谱 电喷雾离子阱质谱联用(LC/MSn)法 .采用LC/MSn联用技术 ,检测家兔灌胃给药后血样和尿样中阿普唑仑原形药及其羟基化代谢物、葡萄糖苷酸型结合物 ,得到了它们的色谱、质谱以及特征碎片离子信息 .阿普唑仑的最低检测限小于 1ng .本法专属性强 ,可推广至其他生物检材的测定 ,尤其适用于需快速响应的临床和法医毒物分析
To establish a liquid chromatography-assisted electrospray ion trap mass spectrometry (LC / MSn) method for the determination of alprazolam and its major metabolites in bodily fluids.Methods: Urinary samples of alprazolam and its hydroxylated metabolites, glucuronide-type conjugates, their chromatographic, mass spectrometry and characteristic fragment ion information, the minimum detection limit of alprazolam less than 1ng. Strong, can be extended to other biological samples of determination, especially for rapid response to clinical and forensic toxicological analysis