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目的:观察芬太尼(多瑞吉)透皮贴剂在中度癌痛的治疗效果,探讨该贴剂使用的最佳时机。方法:选择98例成年癌痛患者,疼痛视觉模拟评分(VAS)为4～6分。芬太尼透皮贴剂从2.5mg剂型开始,每隔3天更换一次,用药时间为15天。治疗过程中观察患者的疼痛评分和药物的不良反应。结果:治疗前后的VAS比较有显著性差异(P<0.01);治疗过程中常见的不良反应为便秘、恶心、呕吐、头晕和嗜睡。结论:芬太尼透皮贴剂能安全用于中度癌痛患者的治疗,推荐使用时机为一、二阶梯镇痛药物常规剂量效果不满意且VAS评分为4～6分的癌痛患者。
Objective: To observe the effect of fentanyl (Doric) transdermal patch on moderate cancer pain and to explore the best time to use the patch. Methods: Ninety-nine adult patients with cancer pain were selected. The pain visual analogue scale (VAS) was 4-6. Fentanyl transdermal patches start from a 2.5 mg dosage form and are changed every 3 days for 15 days. The patient’s pain score and drug adverse reactions were observed during treatment. Results: There was significant difference in VAS before and after treatment (P <0.01). Common adverse reactions during treatment were constipation, nausea, vomiting, dizziness and drowsiness. CONCLUSIONS: Fentanyl transdermal patches are safe for the treatment of patients with moderate cancer pain. The recommended timing for the first and second step analgesics is that they are not satisfied with conventional dose effects and have a VAS score of 4 to 6.