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目的:观察右归饮对中晚期男性广西肝癌细胞端粒酶活性的影响,探讨广西肝癌的肾虚机制。方法:选择经CT或MRI、AFP和肝穿病理确诊的男性中晚期广西肝癌50例,随机分为右归饮组和左归饮组各25例,分别口服右归饮合剂36.67g、左归饮合剂28.33g各50ml,每日三次,连续10个月,比较两组治疗前后主要临床症状及细胞端粒酶活性的变化。结果:右归饮每日110g,服用300天,主要临床症状明显改善、肝癌细胞端粒酶活性显著下降,与本组治疗前比较P<0.01,与左归饮组治疗后比较P<0.01。结论:右归饮对中晚期男性广西肝癌细胞端粒酶活性具有抑制作用,广西肝癌肾阳虚的机制与端粒酶活性的过度表达密切相关。
Objective: To observe the effects of Yougui Yin on the telomerase activity of Guangxi Hepatoma cells in the mid and late stage, and to explore the mechanism of kidney deficiency in Guangxi Hepatoma. Methods: Fifty male patients with advanced hepatocellular carcinoma diagnosed by CT or MRI, AFP and liver biopsy were randomly divided into two groups, 25 cases in Youguiyin group and Zuoguiyin group, respectively. Drink mixture of 28.33g 50ml, three times daily for 10 months, comparing the two groups before and after treatment the main clinical symptoms and changes in telomerase activity. Results: Youguiyin daily 110g, taking 300 days, the main clinical symptoms improved significantly, the telomerase activity of hepatocellular carcinoma cells decreased significantly compared with the group before treatment P <0.01, compared with the Zuogui Yin group after treatment P <0.01. Conclusion: Youguiyin can inhibit the telomerase activity of Guangxi Hepatoma cells in the late stage. The mechanism of kidney-yang deficiency in liver cancer in Guangxi is closely related to the overexpression of telomerase activity.