重度卵巢过度刺激综合征患者的卵母细胞质量:一项自我对照的临床研究

• 作 者: Fa′bregues Frubia J. 刘淑娟
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2005年04期
• 关键词: 卵母细胞质量 卵母细胞 妊娠率 辅助生育技术 胚胎着床 胚胎质量 多囊卵巢综合征 着床率 种植率 促排卵

To investigate the oocyte quality in patients with severe ovarian hyperstimulation syndrome (OHSS). Selfcontrolled clinical study. University teaching hospital. Twentytwo patients from our assisted reproductive technology (ART) program who developed severe OHSS during their first controlled ovarian hyperstimulation for IVF or intracytoplasmic sperm injection (ICSI) (OHSS cycles) during a period of 10 years and had a second ART attempt performed in our center in which OHSS did not develop (control cycles). IVF and ICSI. Oocyte yield and quality, fertilization rate, embryo yield and quality, implantation rate, and pregnancy rate. The total number of oocytes retrieved and the mean number of metaphase II oocytes were significantly higher in patients with OHSS than in control cycles. Fertilization rates were similar in both groups of ART cycles, and thus the number of viable embryos were significantly higher in OHSS cycles. Implantation and pregnancy rates were similar in OHSS and control cycles. Oocyte and embryo yield and quality were similar in early and late OHSS. Oocyte yield and quality, embryological outcome, and implantation and pregnancy rates were similar in patients with and without polycystic ovarian syndrome (PCOS) both in cycles developing OHSS and control cycles. Oocyte quality is not compromised in severe OHSS cycles irrespective of whether patients had or did not have PCOS.

To investigate the oocyte quality in patients with severe ovarian hyperstimulation syndrome (OHSS). Selfcontrolled clinical study. University teaching hospital. Twentytwo patients from our assisted reproductive technology (ART) program who developed severe OHSS during their first controlled ovarian hyperstimulation for IVF or ICSI. Oocyte yield and quality, fertilization rate (OHSS cycles) during a period of 10 years and had a second ART attempt performed in our center in which OHSS did not develop (control cycles) , embryo yield and quality, implantation rate, and pregnancy rate. The total number of oocytes retrieved and the mean number of metaphase II oocytes were significantly higher in patients with OHSS than in control cycles. and thus the number of viable embryos were significantly higher in OHSS cycles. Implantation and pregnancy rates were similar in OHSS and con Oocytes and embryo yield and quality were similar in early and late OHSS. Oocyte yield and quality, embryological outcome, and implantation and pregnancy rates were similar in patients with and without polycystic ovarian syndrome (PCOS) both in cycles developing OHSS and control Oocyte quality is not compromised in severe OHSS cycles irrespective of whether patients had or did not have PCOS.