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目的 测量了新型光敏剂 Ｎ Ｐｅ６（ Ｍ ｏｎｅ Ｌ Ａｓｐａｒｔｙｌ Ｃｈｌｏｒｉｎ ｅ６， Ｎ Ｐｅ６）在白鼠（ Ｂ Ａ Ｌ Ｂ／ Ｃ，雄性）脑组织中的吸收情况，为减少光动力学疗法对正常脑组织的损伤提供关键的实验数据。方法 首次采用了激光诱导荧光产额测量的方法，测得 Ｎ Ｐｅ６ 在脑组织中的吸收情况，并观测激光照射下给予 Ｎ Ｐｅ６ 和未给予组鼠的不同反应。结果 实验测量光敏剂 Ｎ Ｐｅ６ 在鼠脑组织的浓度随时间变化的情况，与已报道的同位素标记方法所得结果一致。观测了激光照射下给药和未给药组鼠的不同反应，发现在相同给药量和激光辐照能量下，随着给药和激光辐照时间间隔的延长，死亡的鼠数目减少；未给药组鼠对激光照射没有可察觉的反应。结论 Ｎ Ｐｅ６ 能被正常脑组织迅速摄取和排除，可望能用于临床
Objective To measure the uptake of a novel photosensitizer N Pe6 (M one L Aspartyl Chlorin e6, N Pe6) in the brain of mice (B AL B/C, male) in order to reduce photodynamic therapy for normal brain tissue The damage provided key experimental data. Methods The method of laser-induced fluorescence yield was used for the first time. The absorption of N Pe6 in brain tissue was measured. The different responses of N Pe6 and non-administered mice under laser irradiation were observed. Results The experimental measurement of the change of the concentration of the photosensitizer N Pe6 in the rat brain tissue over time was consistent with the results obtained from the reported isotope labeling method. The different responses of mice administered with and without laser irradiation were observed, and it was found that with the same dose and laser irradiation energy, the number of dead mice decreased as the time interval between administration and laser irradiation increased; The mice in the administration group had no appreciable reaction to laser irradiation. Conclusion N Pe6 can be rapidly taken up and eliminated by normal brain tissue. It is expected to be used clinically.