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第三章胆汁酸的新陈代谢当静脉给予带有标记的胆固醇时,首先在胆汁中观察到有放射性的胆汁酸,这些胆汁酸到达胃肠中,由于微生物的作用大部分转变为其它胆汁酸,通过肠肝循环返回肝脏,另一部分则随粪便排出体外。一胆固醇分解代谢为一级胆汁酸胆固醇的降解是在肝中进行,Robbins氏清楚地证明即使在摘出的鼠肝中也保持这种能
Chapter 3 Metabolism of Bile Acids When labeled cholesterol is administered intravenously, radioactive bile acids are first observed in the bile. These bile acids reach the gastrointestinal tract, and most of the microorganisms turn into other bile acids because of the action of microorganisms. The enterohepatic circulation returns to the liver, and the other part is excreted with the feces. The degradation of a cholesterol catabolism to a level bile acid cholesterol is performed in the liver, and Robbins clearly demonstrates that this energy can be maintained even in the liver of an exenterated mouse.