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方法：实验用４８只大鼠打击致瘫，其中治疗组２４只在伤后３０分钟注射利多卡因（１５ｍｇ／ｋｇ），以后每天一次。对照组不投药。全部动物分别于伤后第５天、第８天处死并取脊髓标本送检验。结果：实验组动物２４只中有２０只恢复了痛觉和４级运动功能，对照组２４只动物没有功能恢复（Ｐ＜００１）。化验显示，自由基反应产物对照组明显高于实验组（Ｐ＜００１）。结论：结果表明：１利多卡因对脊髓有保护作用；２自由基参与了药理作用。
Methods: Forty-eight rats were challenged with paralysis. Twenty-four rabbits in the treatment group were injected with lidocaine (1.5 mg / kg) 30 minutes after the injury and once daily thereafter. The control group did not administer drugs. All animals were sacrificed on the 5th day, 8th day and sacrificed and sent to the spinal cord specimens for testing. RESULTS: Twenty of the 24 animals in the experimental group recovered the pain and grade 4 motor function, while 24 animals in the control group showed no functional recovery (P <001). Laboratory tests showed that the free radical reaction control group was significantly higher than the experimental group (P <0 01). Conclusion: The results showed that: 1 Lidocaine has a protective effect on the spinal cord; 2 free radicals involved in pharmacological effects.