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用抗氧化剂及自由基清除剂小檗胺（中药提纯单体化合物）对ＳＴＺ诱发的大鼠糖尿病性白内障进行腹腔注射的预防实验结果显示：１）在白内障出现早期小檗胺给药组晶状体空泡出现时间比未给药的糖尿病组推迟２周．２）小檗胺有对抗诱发动物模型晚期晶状体混浊出现的功能，以３．４８ｍｇ／ｋｇ体重剂量的效果最好．３）ＳＯＤ，ＣＡＴ，ＧＳＨ－Ｐｘ酶活性的动态变化，未给药的糖尿病组第２周即开始出现，两个剂量小檗胺给药组均比糖尿病组延迟２周出现．这与裂隙灯观察结果相吻合，但形态学变化晚于酶活性变化．这证明早期使用抗氧化剂及自由基清除剂小檗胺对动物实验性糖尿病性白内障的发生、发展有明显的预防作用．
The results of prophylaxis of intraperitoneal injection of STZ-induced diabetic cataract by berberine, an antioxidant and free radical scavenger, showed that: 1) early berbamine administration in the cataract group showed a decrease in lens capsule Bubble appearance than the non-administered diabetic patients delayed 2 weeks. 2) Berbamine has the function of counteracting the opacification of late lens opacities in animal models, with the best dose of 3.48 mg / kg body weight. 3) The dynamic changes of SOD, CAT and GSH-Px enzyme activities began to appear in the untreated diabetic group at the second week, and the two doses of the berbamine group were delayed by two weeks compared with the diabetic group. This is consistent with the slit lamp observation, but morphological changes later than enzyme activity. This proves that the early use of antioxidants and free-radical scavenger berbamine on animal experimental diabetic cataract development and development have obvious preventive effect.