Effect of VE-cadherin on sentitivity to Imatinib in Sup-B15 Philadelphia chromosome positive acute l

• 作 者: 张焕新
• 机 构: Dept Hematol,Affil Hosp,Xuzhou Med Coll,
• 出 处: China Medical Abstracts(Internal Medicine)
• 发表日期: 2013年03期
• 关键词: lymphoblastic cadherin chromosome Philadelphia mesylate catenin stably RNA sensi

Objective To investigate the sensitivity of imatinib mesylate (IM) on Sup-B15 Ph+acute lymphoblastic leukemia (ALL) cells knockdown of VE-cadherin (CD144) ,and to further explore its mechanism.Methods CD144in Sup-B15 leukemia cells was stably knockdowned via lentivirus-mediated RNA interference (named as

Objective To investigate the sensitivity of imatinib mesylate (IM) on Sup-B15 Ph + acute lymphoblastic leukemia (ALL) cells knockdown of VE-cadherin (CD144), and to further explore its mechanism. Methods CD144in Sup-B15 leukemia cells was stably knockdowned via lentivirus-mediated RNA interference (named as