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目的 :探讨大豆异黄酮(soybean isoflavones,SIF)改善阿茨海默病(Alzheimer’s disease,AD)大鼠学习记忆能力的作用机制。方法 :采用右侧杏仁核注射β-淀粉样肽(β-amyloid peptide,Aβ)制备AD大鼠模型,给予不同剂量的SIF,观察其对大鼠海马胆碱乙酰转移酶(choline acetyltransferase,ChAT)活性和半胱天冬氨酸特异性蛋白酶3(cysteinyl aspartate-specific protease3,caspase-3)活性的影响。结果 :大豆异黄酮显著升高AD大鼠海马ChAT活性,降低AD大鼠海马caspase-3活性。结论 :大豆异黄酮对中枢胆碱能神经细胞损伤及脑细胞凋亡具有保护作用,能改善AD大鼠学习记忆能力。
Objective: To investigate the mechanism of soybean isoflavones (SIF) on learning and memory in Alzheimer’s disease (AD) rats. Methods: A rat model of Alzheimer’s disease (AD) was established by injecting β-amyloid peptide (Aβ) into the right amygdala. Various doses of SIF were administered to rats. The effects of choline acetyltransferase (ChAT) Activity and caspase-3 activity of cysteinyl aspartate-specific protease 3 (caspase-3). Results: Soy isoflavones significantly increased ChAT activity in hippocampus of AD rats and decreased caspase-3 activity in hippocampus of AD rats. Conclusion: Soy isoflavones have a protective effect on central cholinergic nerve cell injury and brain cell apoptosis, which can improve the learning and memory abilities of AD rats.