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目的观察稳心颗粒与美托洛尔在老年患者房性早搏治疗中的临床疗效及相应的不良反应。方法 80例老年(年龄≥65岁)房性早搏患者,随机分为治疗组(42例)和对照组(38例)。治疗组口服稳心颗粒,对照组口服美托洛尔。4周后复查动态心电图(Holter),观察疗效及不良反应。结果治疗组总有效率为83.3%,对照组为86.8%,比较差异无统计学意义(P>0.05);治疗组不良反应明显少于对照组,差异具有统计学意义(P<0.05)。结论稳心颗粒治疗房性早搏的疗效与美托洛尔相当,且不良反应较少,特别适合于老年有β受体阻滞剂禁忌证的患者,值得临床推广。
Objective To observe the clinical effect of Wenxin Granule and metoprolol in the treatment of atrial premature beats in elderly patients and the corresponding adverse reactions. Methods Eighty elderly patients (≥65 years old) with atrial premature beats were randomly divided into treatment group (n = 42) and control group (n = 38). The treatment group oral Wenxin particles, the control group oral metoprolol. After 4 weeks review of Holter, observe the efficacy and adverse reactions. Results The total effective rate was 83.3% in the treatment group and 86.8% in the control group, with no significant difference (P> 0.05). The adverse reactions in the treatment group were significantly less than those in the control group (P <0.05). Conclusion Wenxin Granule is equivalent to metoprolol in the treatment of atrial premature beats and has fewer side effects. It is especially suitable for patients with contraindications of β-blockers in the elderly and is worthy of clinical promotion.