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一种含环氧基成分的抗肿瘤物质的生产是从罂粟油中除去饱和脂肪酸,用双氧水处理,溶于的无水乙醇层物在5C静置,蒸去醇得到含有环氧基的不饱和脂肪酸酯。该物显示抗肿瘤活性,低毒,可用于制药。从罂粟种子中得到罂粟油,加入等量的饱和KOH溶液,混合物煮沸,搅30min,在其中加入冷硫酸,除去饱和脂肪酸,用5％HCl清洗上层液,再用10％NaHCO_2洗涤,加入1/3体积的双氧水,混合物在10C搅30min,将上清液溶于无水乙醇中并在冷却下回流,得
An epoxy-containing antitumor substance is produced by removing saturated fatty acids from poppy oil, treating with hydrogen peroxide, and dissolving the absolute ethanol layer at 5C, and distilling the alcohol to obtain an epoxy-containing unsaturated group. Fatty acid esters. The substance shows anti-tumor activity, low toxicity, and can be used in pharmaceuticals. Poppy oil was obtained from poppy seeds, an equal amount of saturated KOH solution was added, the mixture was boiled, stirred for 30 min, cold sulfuric acid was added thereto, saturated fatty acids were removed, the supernatant was washed with 5% HCl, and washed with 10% NaHCO 2 to add 1/ 3 volumes of hydrogen peroxide, the mixture was stirred at 10C for 30 min, the supernatant was dissolved in anhydrous ethanol and refluxed under cooling.