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人类衰老最主要的淋巴组织缺陷是重症联合性免疫缺陷病(SCID)。目前,这种常染色体隐性遗传病唯一已知的模型是SCID—阿拉伯马驹。近交系小鼠C·B-17[BALB/c·C 57 BL/Ka-Igh-a~b/ICR(N 17F 34)]可能成为重症联合性免疫缺陷病模型。经测试各种试验性杂交的600多后裔,结论为:scid基因以单一隐性正染色体方式分离,并不与免疫球蛋白重链位点或主要组织相容性位点连接。这种小鼠的B和T淋巴细胞功能均有缺陷,白细胞数降低,淋巴器官减少,缺乏可测水平的B细胞。多数个
The most important lymphoid tissue defect in human aging is severe combined immunodeficiency disease (SCID). Currently, the only known model of this autosomal recessive disease is the SCID-Arabian horse. Inbred mice C · B-17 [BALB / c · C 57 BL / Ka-Igh-a ~ b / ICR (N 17F 34)] may become severe combined immunodeficiency disease model. After testing more than 600 descendants of various experimental crosses, it was concluded that the scid gene was isolated as a single recessive orthosteric chromosome and was not linked to immunoglobulin heavy chain sites or major histocompatibility sites. This mouse has defective B and T lymphocyte functions, reduced white blood cell count, reduced lymphoid organs, and lack of measurable levels of B cells. Mostly