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目前,耐甲氧西林金黄色葡萄球菌(Methieilli-Resistant Staphylococcus Aureus,MRSA)是医院感染或术后感染的重要病原菌之一,其耐药特性及流行病学特征已成为医务工作者关注的热点。研究表明,MRSA耐甲氧西林的主要机制是染色体mecA基因编码表达一独特型青霉素结合蛋白(PBP_2a),但MRSA菌株的耐药表型各异。MRSA分流行株和非流行株,流行菌株又各具特征。已证实单克隆MRSA菌株可导致爆发流行,及时发现流行菌株,对防止其播散流行具有重要意义。
Currently, Methicilli-resistant Staphylococcus Aureus (MRSA) is one of the most important pathogens in nosocomial infections and postoperative infections. Its drug resistance and epidemiological characteristics have become the focus of medical workers. Studies have shown that the main mechanism of methicillin-resistant MRSA is that the chromosome mecA gene encodes a unique type of penicillin-binding protein (PBP_2a), but the MRSA strains have different drug resistance phenotypes. MRSA sub-strains and non-epidemic strains, strains have their own characteristics. It has been confirmed that monoclonal MRSA strains can cause outbreaks and timely detection of epidemic strains, which is of great significance in preventing the spread of the epidemic.