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目的研究葛根素在肥胖型多囊卵巢综合征(PCOS)治疗过程中的抗氧化应激作用。方法收集30例肥胖型PCOS患者,随机分为肥胖型治疗组15例和肥胖型对照组15例,收集15例瘦型PCOS患者设为瘦型治疗组。肥胖型对照组只给予达英35和二甲双胍治疗,肥胖型PCOS治疗组和瘦型治疗组除以上治疗外,还给予葛根素口服,疗程均为3个月。收集治疗前后3组的数据,系统评价葛根素对3组PCOS患者在改善临床症状、激素水平、生化指标和抗氧化能力等方面的有效性和安全性。结果葛根素可改善肥胖型PCOS患者的闭经情况,且体质量指数(BMI)纠正比瘦型者好;可降低肥胖型PCOS患者的游离雄激素、胰岛素抵抗;可以升高肥胖型PCOS患者的高密度脂蛋白胆固醇(HDL-C),降低瘦型者的甘油三酯(TG);可加强肥胖型PCOS患者中酶类谷胱甘肽过氧化物酶(GPX)、非酶类维生素E(Vit E)的抗氧化能力,而对于瘦型PCOS患者服用葛根素的抗氧化能力纠正更强。无论肥瘦,葛根素均可提高Vit E的抗氧化能力,但不能改变催乳素(PRL)、雌酮(E1)/雌二醇(E2)>1。结论葛根素治疗PCOS患者作用靶点在于对抗高雄激素、胰岛素抵抗和脂质代谢异常,并提高抗氧化能力,前3点肥胖者明显,抗氧化则瘦型者明显。
Objective To study the anti-oxidative stress effects of puerarin in the treatment of obese patients with polycystic ovary syndrome (PCOS). Methods A total of 30 obese patients with PCOS were collected and randomly divided into 15 obese patients and 15 obese patients. Fifteen patients with lean PCOS were recruited as lean-type patients. Obese control group only given up to 35 and metformin treatment, obese PCOS treatment group and the lean-type treatment group in addition to the above treatment, but also to give puerarin orally, the course of treatment were 3 months. The data of 3 groups before and after treatment were collected to evaluate the effectiveness and safety of puerarin in improving PCOS patients’ clinical symptoms, hormone levels, biochemical indexes and antioxidant capacity. Results Puerarin could ameliorate amenorrhea in obese patients with PCOS, and body mass index (BMI) correction was better than lean type; it could reduce free androgen and insulin resistance in obese patients with PCOS; Density lipoprotein cholesterol (HDL-C), reduce triglyceride (TG) in lean type; strengthen the enzyme glutathione peroxidase (GPX), non-enzyme vitamin E E) antioxidant capacity, and for patients with lean PCOS take puerarin antioxidant capacity to correct more. Both fat and fat, puerarin can increase the antioxidant capacity of Vit E, but can not change the prolactin (PRL), estrone (E1) / estradiol (E2)> 1. Conclusion The therapeutic target of puerarin in patients with PCOS is to antagonize hyperandrogenism, insulin resistance and abnormal lipid metabolism, and to improve the anti-oxidative capacity. Obesity is obvious in the first 3 o’clock and the anti-oxidant is obviously lean.