Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue

• 作 者: Qin-Xian Zhang YI Ding ZHUO Li Xiao-Ping Le Wei Zhang Ling Sun Hui-Rong Shi
• 机 构: Molecular Cell Biology Research Center, Medical College of Zhengzhou University, Zhengzhou 450052, H
• 出 处: 世界胃肠病学杂志(英文版)
• 发表日期: 2004年12期
• 关键词: gastric tissue gastric cancer nuclear matrix proteins clinical stages

AIM: To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer.METHODS: The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software.RESULTS: Compared with normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly (P=0.002, P=0.001, P＜0.05). No significant difference was found in the expression of the two NMPs between the various differentiated grades (P=0.947, P=0.356) and clinical stages of gastric cancer (P=0.920, P=0.243, P＞0.05).CONCLUSION: The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.