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目的:探讨中医周期辨证疗法联合来曲唑治疗青春型多囊卵巢综合征的临床疗效。方法:将60例青春型多囊卵巢综合征患者随机分为对照组和治疗组,每组30例,对照组用来曲唑治疗,治疗组予中医周期辨证疗法联合来曲唑治疗,连续治疗3个月经周期,观察两组患者临床疗效、中医证候积分变化及内分泌激素(FSH、LH、PRL、DHEA-S)变化等指标。结果:治疗后,治疗组临床总有效率为80.0%,明显高于对照组的63.3%,差异有统计学意义(P<0.05);两组患者中医证候积分较前均有明显降低,但治疗组变化更显著,差异均有统计学意义(P<0.05);治疗后两组LH/FSH比值、PRL及DHEA-S较治疗前均降低,两组组内治疗前后比较,差异均有统计学意义(P<0.05);治疗后两组组间比较,差异无统计学意义(P>0.05)。结论:中医周期辨证疗法联合来曲唑治疗青春型多囊卵巢综合征的临床疗效显著,可明显改善临床症状及有效降低FSH、LH、PRL、DHEA-S等激素水平。
Objective: To investigate the clinical efficacy of TCM syndrome differentiation combined with letrozole in treating polycystic ovary syndrome of youth. Methods: Sixty patients with polycystic ovary syndrome were randomly divided into control group and treatment group, with 30 cases in each group. The control group was treated with letrozole. The treatment group was treated with TCM syndrome differentiation combined with letrozole and continuous treatment Three menstrual cycles, the clinical efficacy of two groups were observed, TCM syndrome score changes and changes in endocrine hormones (FSH, LH, PRL, DHEA-S) and other indicators. Results: After treatment, the total clinical effective rate was 80.0% in the treatment group, which was significantly higher than 63.3% in the control group (P <0.05). The scores of TCM syndromes in both groups were significantly lower than those before (P <0.05). After treatment, the ratio of LH / FSH, PRL and DHEA-S in the two groups were significantly lower than those before treatment, both before and after treatment in the two groups were statistically significant (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05). Conclusion: The TCM syndrome differentiation therapy combined with letrozole in the treatment of polycystic ovary syndrome of youth has obvious curative effect, can obviously improve the clinical symptoms and effectively reduce the levels of hormones such as FSH, LH, PRL and DHEA-S.