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目的:分析何首乌致药物性肝损伤的临床特点,以期引起临床的重视。方法:回顾性分析因口服何首乌及其制剂导致药物性肝损伤的52例住院患者的临床资料。结果:从服药到发病最短5天,最长4个月,大多在2周;肝损伤类型:肝细胞损伤型30例(占58%),胆汁淤积型9例(占17%),混合型13例(占25%)。全部患者经停用何首乌及其制剂、积极护肝等治疗痊愈出院。结论:在临床工作中应规范使用何首乌及其制剂,对应用何首乌及其制剂者应严密监测肝功能,一旦发现肝损伤,及时停药并给予护肝治疗,大多预后良好。
Objective: To analyze the clinical characteristics of Polygonum multiflorum L. induced by drug-induced liver injury in order to arouse clinical attention. Methods: The clinical data of 52 inpatients with drug-induced liver injury caused by oral administration of Polygonum multiflorum and its preparations were retrospectively analyzed. Results: From the medication to the shortest onset of 5 days, up to 4 months, mostly in 2 weeks; liver injury: hepatocellular injury in 30 cases (58%), cholestasis in 9 cases (17%), 13 cases (25%). All patients with Polygonum multiflorum and its preparation, active treatment of liver cured and discharged. Conclusion: Polygonum multiflorum and its preparations should be used in clinical practice. Hepatic function should be closely monitored in the application of Polygonum multiflorum and its preparation. Once the liver injury is found, drug withdrawal and liver protection are given in time, the prognosis is good.