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目的探讨左乙拉西坦(LEV)与拉莫三嗪(LTG)单药治疗伴中央颞区棘波的儿童良性癫痫(BECTS)患儿对认知功能的影响。方法选取52例BECTS患儿,治疗前及治疗6个月后分别进行智力测试及事件相关电位P300检查,并比较二者结果之间的差异。结果 (1)LEV治疗后P300潜伏期、智力测试与治疗前比较,t=2.327、-6.194,差异有统计学意义(P<0.05);(2)LTG治疗后P300潜伏期、智力测试与治疗前比较,t=4.391、-10.445,差异有统计学意义(P<0.05);(3)LEV与LTG单药治疗后P300潜伏期t=1.392,智力测试t=-1.387,差异无统计学意义(P>0.05)。结论 LEV与LTG均通过有效抑制癫痫样放电,进而改善患儿智力水平,两药之间对比对智力影响差异无统计学意义。
Objective To investigate the effects of levetiracetam (LEV) and lamotrigine (LTG) monotherapy on cognitive function in children with benign epilepsy (BECTS) with central temporal spikes. Methods Totally 52 children with BECTS were selected, and their mental tests and P300 were performed before treatment and 6 months after treatment, and the differences between the two were compared. Results (1) The latency and intelligence test of P300 after LEV treatment were compared with those before treatment, t = 2.327, -6.194, the difference was statistically significant (P <0.05); (2) P300 latency and intelligence test after LTG treatment were , t = 4.391, -10.445, respectively (P <0.05); (3) After incubation with LEV and LTG, the latency of P300 was t = 1.392 and t = -1.387, the difference was not statistically significant (P> 0.05). Conclusions Both LEV and LTG can effectively reduce the epileptiform discharge and improve the mental status of children. There is no significant difference between the two groups in the effect of intelligence on intelligence.