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目的探讨慢性乙型肝炎患者CD8+CD28+T/CD8+CD28-T比值变化及临床意义。方法 流式细胞仪测定正常对照、慢性乙型肝炎患者CD8+CD28+T/CD8+CD28-T的百分数,并计算CD8+CD28+T/CD8+CD28-T比值,慢性乙型肝炎组根据HBV-DNA含量分为两组,低病毒载量组(HBV-DNA<106拷贝/ml)和高病毒载量组(HBV-DNA>106拷贝/ml),并分别计算CD8+CD28+T/CD8+CD28-T比值。结果慢性乙型肝炎患者组CD8+CD28+T/CD8+CD28-T比值与正常对照组相比明显降低,两者差异有统计学意义(P<0.01);慢性乙型肝炎高病毒载量组CD8+CD28+T/CD8+CD28-T比值低于低病毒载量组(P=0.039),两组差异有统计学意义。结论 慢性乙型肝炎患者CD8+CD28+T/CD8+CD28-T比值下降可能是病毒不能清除,而长期存在的原因之一。
Objective To investigate the changes of CD8 + CD28 + T / CD8 + CD28-T ratio in patients with chronic hepatitis B and its clinical significance. Methods The percentages of CD8 + CD28 + T / CD8 + CD28-T in patients with chronic hepatitis B were determined by flow cytometry. The ratio of CD8 + CD28 + T / CD8 + CD28- DNA content was divided into two groups: low viral load group (HBV-DNA <106 copies / ml) and high viral load group (HBV-DNA> 106 copies / ml), and calculated CD8 + CD28 + T / CD8 + CD28-T ratio. Results The ratio of CD8 + CD28 + T / CD8 + CD28-T in patients with chronic hepatitis B was significantly lower than that in the control group (P <0.01) CD8 + CD28 + T / CD8 + CD28-T ratio was lower than the low viral load group (P = 0.039), the difference between the two groups was statistically significant. Conclusion The decrease of CD8 + CD28 + T / CD8 + CD28-T ratio in patients with chronic hepatitis B may be one of the reasons that the virus can not be eliminated for a long time.