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目的探讨端粒酶催化亚单位(hTERT)与子宫腺肌病发生、发展的可能机制。方法 2006年1月至2009年8月在山西医科大学第一医院采用免疫组化SP法测定并比较70例因子宫腺肌病切除子宫的患者在位及异位子宫内膜和24例因宫颈上皮内瘤变(CIN)Ⅲ切除子宫的患者在位子宫内膜组织中端粒酶的表达阳性率。结果子宫腺肌病患者在位、异位子宫内膜组织与CINⅢ患者子宫内膜组织hTERT表达阳性率分别为45.7%、70.0%和20.8%,3组比较差异有统计学意义(P<0.05)。研究组弥漫型与局限型hTERT表达阳性率差异无统计学意义(P>0.05)。研究组增殖期与分泌期hTERT表达阳性率分别为90.5%和64.7%,差异有统计学意义(P<0.05)。hTRET阳性表达率在研究组子宫体积的比较中差异有统计学意义(P<0.05)。研究组有月经改变组和无月经改变组hTERT表达阳性率差异无统计学意义(P>0.05)。结论 hTERT的高表达与子宫腺肌病及病变进展程度有关。
Objective To explore the possible mechanism of the occurrence and development of telomerase catalytic subunit (hTERT) and adenomyosis. Methods January 2006 to August 2009 in the First Hospital of Shanxi Medical University immunohistochemical SP method to determine and compare 70 cases of adenomyosis in patients with ectopic and ectopic endometrium and 24 cases of endometriosis The positive rate of telomerase expression in the endometrial tissue of patients with intraepithelial neoplasia (CIN) Ⅲ excision. Results The positive rates of hTERT expression in eutopic and ectopic endometrial tissues and endometrial tissues of patients with CIN Ⅲ were 45.7%, 70.0% and 20.8%, respectively (P <0.05) . There was no significant difference in the positive rates of diffuse and localized hTERT between the two groups (P> 0.05). The positive rates of hTERT expression in the proliferative phase and secretory phase in the study group were 90.5% and 64.7%, respectively, with statistical significance (P <0.05). The hTRET positive expression rate in the study group uterine volume difference was statistically significant (P <0.05). There was no significant difference in the positive expression rate of hTERT in study group between menstruation group and non-menstrual group (P> 0.05). Conclusion The high expression of hTERT is associated with the progression of adenomyosis and lesions.