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目的分析慢性乙型肝炎病毒携带者血清HBV DNA定量与肝组织病理炎症相关性,以判定是否以1×105拷贝/ml作为进行肝组织活检的标准。方法选取慢性乙型肝炎病毒携带者244例,行肝穿刺病理检查、肝功能、HBV DNA、乙肝标志物,依据血清HBV DNA将患者分为高载量(≥105)和低载量(<105)两组,同时依据肝脏炎症程度分级分0.05),0.05)。结论多数慢性乙型肝炎病毒携带者有轻度炎症,炎症分级G≥2者占19.7%;肝脏炎症程度与血清HBVDNA无相关性,1×105拷贝/ml不能作为是否进行肝组织活检的标准。
Objective To analyze the relationship between serum HBV DNA and histopathological inflammation in patients with chronic hepatitis B virus infection and to determine if 1 × 105 copies / ml is the standard for performing liver biopsy. Methods Totally 244 patients with chronic hepatitis B virus infection were enrolled in this study. Liver biopsy, liver function, HBV DNA and hepatitis B were detected. Serum HBV DNA was used to divide patients into high-load (≥105) and low-load ) Two groups, according to the degree of liver inflammation grading 0.05), 0.05). Conclusions Most patients with chronic hepatitis B virus have mild inflammation, 19.7% with inflammation grade G≥2. There is no correlation between the severity of liver inflammation and serum HBVDNA, and 1 × 105 copies / ml can not be used as the standard for biopsy of liver tissue.