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在毒理学研究中,实验设计和资料分析所致的差异,可从根本上影响所得的结果。例如,在一次剂量灌胃的毒性研究和对眼、皮肤刺激作用的研究中,即使采用一种固定的实验操作方法,其结果变异甚大。在8个实验室中,应用由一个饲养场供应的同种大鼠,样品均取自210种化学物质的同一样本,当作急性灌胃实验时,其中一个实验室对所有样品一致地获得了较高的LD_(50),而另一个实验室则得到较低的LD_(50)。实验室之间的变异性,通常是由于操作方法不同所致,而不包括毒理学方面应用的动物。因此,在预测对人安全或危害的长期毒性研究的设计和实验时,必须予以足够的重视。
In toxicology research, differences between experimental design and data analysis can fundamentally affect the results obtained. For example, in one dose of gavage toxicity studies and studies of eye and skin irritation, the results vary widely even with a fixed experimental procedure. In eight laboratories, the same type of rats supplied from one farm were used and the samples were taken from the same sample of 210 chemicals. When used as an acute gavage test, one of the laboratories consistently obtained all the samples Higher LD_ (50), while the other lab gets a lower LD_ (50). Laboratory variability, usually due to different methods of operation, not including toxicology applications of animals. Therefore, adequate consideration must be given to the design and testing of long-term toxicity studies that predict the safety or harm to humans.