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缺血性脑卒中后脑损伤的机制十分复杂,涉及钙超载、兴奋性毒性、氧自由基损伤等。近年来随着膜片钳电生理技术的广泛应用,脑缺血早期Na+通道的下调对神经元的保护机制已逐渐引起人们的重视。大量研究证明:Na+通道阻滞剂具有明显的脑保护作用。现就Na+通道与缺血性脑卒中的关系
The mechanism of brain injury after ischemic stroke is very complex, involving calcium overload, excitotoxicity, oxygen free radical damage and so on. In recent years, with the extensive application of patch clamp electrophysiology, the mechanism of neuronal protection has been gradually paid more attention by the down-regulation of Na + channel in early stage of cerebral ischemia. Numerous studies have shown that: Na + channel blockers have a significant brain protective effect. Now on the Na + channel and ischemic stroke